Jessica Briles was born in St. Louis, Missouri. When she was six years old, her family moved to Altotonga, Veracruz, Mexico. She lived there for nine years and then moved to New Braunfels, Texas. After graduating from high school in May of 2011, she was pretty sure God was calling her to missions. She decided not to pursue college immediately and went instead to Oaxaca, Mexico, to work and minister at an orphanage for a few months. She now lives and serves full-time at the same orphanage, Casa Hogar Benito Juarez.